Specialist Pathology Testing

The IgG4 General Foods 96 Foods Panel is a comprehensive test designed to assess immune responses to commonly consumed foods by measuring Immunoglobulin G4 (IgG4) antibodies. IgG4 is a subtype of Immunoglobulin G, and its presence can indicate delayed food sensitivities that may contribute to chronic health issues such as digestive discomfort, skin conditions, headaches, and fatigue. Unlike other IgG subtypes, IgG4 responses are typically associated with immune tolerance, making it particularly useful in identifying subtle or long-term sensitivities. This test evaluates 96 common foods, providing an extensive overview of potential food triggers.

Cytokines are chemical messengers that primarily signal the immune system, but also play a role as neuromodulators. They can be defined as either pro-inflammatory or anti-inflammatory. Cytokine imbalances may be involved in autoimmune disorders, atopic conditions, and neuropsychiatric disorders. Generally, pro-inflammatory cytokines are secreted from T-helper 1 (Th1) cells and anti-inflammatory cytokines from T-helper 2 (Th2) cells. Under normal circumstances the Th1 and Th2 systems should be in balance.

A balanced diet should be sufficient to provide optimal amounts of essential nutrients. However, in today's world of compromised eating habits, environmental stresses, and nutrient-depleted fresh and processed foods, optimal levels of essential elements within the body are not guaranteed. Trace and essential elements are vital for nearly all chemical reactions in the body. This test is unique in that a wide range of minerals can be measured in one sample to provide status of cellular activity and nutrient metabolism.

The HLA DR/DQ gene analyses two important genomic markers, HLA-DQB1 and HLA-DR, that can reveal important information relating to autoimmune disorders as well as inflammatory disorders. Approximately 25% of the world's population have one of the 10 susceptible types of HLA DR/DQ genes. The HLA DR/DQ gene test shows haplotypes (gene combinations) which show susceptibility to mould, Lyme, and related conditions.

The myDNA Comprehensive Health Report supports practitioners to deliver holistic and preventative approaches to health. DNA is an important piece of the puzzle that can help guide behaviour change and treatment decisions. This report examines specific genetic markers offering personalised insight to get to the root of health issues or as a proactive solution to optimise health and wellness. The test covers 92 genes and 113 SNPs across Digestion, Energy, Hormones, Stress & Cognitive Performance, Inflammation, Athletic Performance, DNA Protection & Repair, and Detoxification.

The Adrenocortex hormone profile is a non-invasive saliva test that serves as a reliable marker of stress response and a critical tool for revealing adrenal imbalances. Lifestyle, physical, and psychological stresses put constant demands on the adrenal glands. If they become depleted, adrenal fatigue or insufficiency may be experienced. Salivary cortisol testing evaluates bioactive levels of the body's stress hormones, cortisol and DHEA, serving as a critical tool for uncovering biochemical imbalances. This test examines 4 saliva samples over a 12-hour period.

Hormones are crucial to a woman's reproductive health. The main hormones affecting the menstrual cycle and fertility are produced by glands in the brain and by the ovaries. These hormones regulate menstruation, fertility, and sex drive (libido), any of which can be adversely affected if hormone production goes out of balance. As most women approach mid-life, hormonal changes gradually cause reproductive organs to shut down, eventually leading to menopause. All hormone systems work in concert to maintain balance.

The aging male experiences a decrease in testosterone at a rate of 10% per decade from the age of 30. This reduction of testosterone and other androgens experienced through ageing has been named andropause, or androgen deficiency of the ageing male (ADAM). This profile provides valuable information on hormonal status and insights into a wide range of disorders, from reduced libido and muscle mass to cardiovascular disease and other hormone-related imbalances. Salivary hormone testing is particularly ideal for prevention and treatment of hormone-related symptoms, prescribing and monitoring Hormone Replacement Therapy (HRT).

Growth hormone (GH) stimulates nearly every tissue in the body and has an anabolic function. Adult-onset growth hormone deficiency is common and can present as central obesity, diminished memory, impaired sleep, low libido, osteoporosis, and cardiovascular disease. By diagnosing and treating the decline of GH, age-related changes in body composition, mood, and overall quality of life can be improved. Numerous studies using GH therapy in the ageing population have shown improvements in lean muscle mass, total body fat, bone, and cardiovascular parameters. GH is a peptide hormone secreted from the anterior pituitary gland and its secretion occurs in a pulsatile fashion with the main peak occurring at 12–1 am in healthy adults.

The Sleep Profile is a non-invasive saliva test that assesses two major causes of insomnia: imbalances in melatonin and cortisol. Melatonin is a peptide hormone produced by the pineal gland which helps control normal sleep patterns. Deficiencies can lead to insomnia. Imbalances in the diurnal pattern of cortisol can also disturb sleep. Insomnia is defined as repeated difficulty with sleep initiation, maintenance, duration, or quality. Mild insomnia affects between 30–50% of the general population, while chronic insomnia affects 9–15%. This test is ideal for shift workers, who often experience cortisol and melatonin imbalances.

Vitamin D is crucial for bone strength and may have implications on other medical conditions including osteoporosis, cancer, multiple sclerosis, and type 1 and type 2 diabetes. Our test measures the levels of vitamin D (total, 25-hydroxy D2 and D3) in the blood. An ideal assessment for screening as well as monitoring supplementation progress.

The Extensive Neurotransmitter Profile is a urine test assessing levels of 6 neurotransmitters: serotonin, GABA, dopamine, noradrenaline, adrenaline, and glutamate. These neurotransmitters are the most researched in relation to their effects on mood disorders, hormones, sleep, glucose/insulin balance, pain perception, appetite, and cognitive function.

The CDSA can help healthcare professionals develop earlier, more effective preventive interventions, improve the timing and precision of treatments, and reduce the risk of clinical relapse. The CDSA Level 1 is a comprehensive assessment of the microbiological environment of the gut, including macroscopy, microscopy, bacteriology, mycology (yeasts), and parasitology. This test reports on pathogenic and imbalanced colonising organisms as well as identifying the levels of beneficial flora. It's a cost-effective option to confirm or exclude dysbiosis.

Amino acids play central roles both as building blocks of proteins and as intermediates in metabolism, catalysing most cellular processes. Conditions as varied as chemical sensitivities, cardiovascular disease, macular degeneration, bone disorders, and insomnia are associated with amino acid imbalances. Amino acids are required for neurotransmitter and hormone production, including glutamate, histidine, tyrosine, tryptophan, arginine, ornithine, and glutamine. They are also central to liver detoxification, connective tissue, muscle metabolism, and the cellular energy cycle.

Current public health recommendations to restrict salt intake, combined with a decline in iodophors in dairy and bread production, has contributed to the re-emergence of iodine deficiency. Iodine is required for thyroid hormone synthesis, and deficiency presents with hypothyroid symptoms. Severe iodine deficiency in Australia has more than quadrupled over the last 20 years, from 2.6% to 11.7%. The Iodine Loading Test assesses deficiency by measuring iodine levels in a morning spot urine, then analyses retention via a 50mg loading dose with measurement over the next 24 hours. If iodine-deficient, the body retains the iodine and excretes less.

The Autoimmune Assessment Panel is an advanced test designed to detect autoimmune diseases, in which the immune system mistakenly targets the body's own tissues. It identifies key biomarkers crucial for diagnosing conditions such as Rheumatoid Arthritis, Lupus, and Sjögren's Syndrome. Elevated ANA levels are commonly seen in systemic diseases like Lupus, while RF is typically higher in Rheumatoid Arthritis. Anti-CCP antibodies are highly specific to Rheumatoid Arthritis. ENA identifies antibodies linked to connective tissue diseases, dsDNA is particularly associated with Lupus, and AMA is linked to primary biliary cholangitis. Early diagnosis allows for more effective management and the prevention of complications.

Electrolytes are important minerals found in the body. Optimal levels keep the body's fluids in balance and help your body function healthily. Electrolytes move fluid in and out of cells, carry nutrients into cells and waste products back out, and help the acids and bases in your blood stay in balance. NutriPATH's electrolytes panel assesses 7 key crucial elements that provide clinically useful information of a patient's overall electrolyte status. Imbalances are quite common and can lead to dysfunction in vital body systems, including muscles and brain.

Iron is an essential trace element mainly derived from dietary sources. Iron is needed to assist in the formation of adequate numbers of normal red blood cells, which carry oxygen throughout the body. Iron is a critical part of haemoglobin, the protein that binds oxygen in the lungs and releases it as blood travels around the body. Iron is also needed by other cells, especially muscle. Low iron levels can lead to anaemia, in which the body does not have enough red blood cells.

Telomeres are protective caps at the ends of chromosomes, composed of repeated DNA sequences and specialised proteins. They play a critical role in shielding chromosomes from damage. Over time, telomeres shorten with each cell division, contributing to cellular ageing and senescence. These changes are linked to age-related diseases, driven by telomere dysfunction. Healthy lifestyle interventions (exercise, balanced diet, certain therapies) have been shown to limit the effects of senescence. Telomere testing provides valuable insights into biological ageing and helps identify risks for age-associated conditions, so you can take proactive steps to improve longevity.